|
Total number, n (%)
|
172 (100)
|
48 (27.9)
|
82 (47.7)
|
42 (24.4)
| |
|
Sociodemographic variables
|
|
Age, mean (SD), years
|
60.5 (17.0)
|
39.0 (8.3)
|
62.1 (6.5)
|
81.9 (5.5)
|
< 0.001
|
|
Sex, n (%)
|
|
Female
|
87 (50.6)
|
25 (52.0)
|
32 (39)
|
30 (71)
|
0.003
|
|
Male
|
85 (49.4)
|
23 (48.0)
|
50 (61)
|
12 (29)
| |
|
Comorbidities
|
|
Cardiovascular risk factor
|
|
Smoke habit, n (%)
|
13 (7.6)
|
3 (6)
|
10 (12)
|
0 (0)
|
0.062
|
|
BMI ≥ 25 kg/m2, n (%)
|
90 (52.3)
|
16 (33)
|
51 (62)
|
23 (55)
|
0.012
|
|
Hypertension, n (%)
|
83 (48.3)
|
6 (12)
|
39 (48)
|
38 (90)
|
< 0.001
|
|
type 2 Diabetes, n (%)
|
33 (19.2)
|
0 (0)
|
21 (26)
|
12 (29)
|
< 0.001
|
|
Dyslipidemia, n (%)
|
68 (39.5)
|
11 (23)
|
32 (39)
|
25 (60)
|
0.002
|
|
Respiratory diseases
|
|
Asthma, n (%)
|
21 (12.2)
|
4 (8)
|
7 (9)
|
10 (24)
|
0.031
|
|
COPD, n (%)
|
9 (5.2)
|
1 (2)
|
5 (6)
|
3 (7)
|
0.50
|
|
Cardiovascular diseases
|
|
Ischaemic heart diseases, n (%)
|
9 (5.2)
|
0 (0)
|
3 (4)
|
6 (14)
|
0.007
|
|
Arrhythmias, n (%)
|
10 (5.8)
|
1 (2)
|
2 (2)
|
7 (17)
|
0.003
|
|
Heart failure, n (%)
|
7 (4.1)
|
0 (0)
|
3 (4)
|
4 (10)
|
0.072
|
|
Other diseases
|
|
Chronic kidney diseases, n (%)
|
12 (7.0)
|
0 (0)
|
3 (4)
|
9 (21)
|
< 0.001
|
|
Cognitive impairment, n (%)
|
10 (5.8)
|
1 (2)
|
1 (1)
|
8 (19)
|
< 0.001
|
|
Cancer, n (%)
|
10 (5.8)
|
0 (0)
|
4 (5)
|
6 (14)
|
0.014
|
|
Rheumatological diseases, n (%)
|
14 (8.1)
|
3 (6)
|
6 (7)
|
5 (12)
|
0.58
|
|
Chronic treatment
|
|
no drugs, n (%)
|
33 (19.2)
|
19 (40)
|
14 (17)
|
0 (0)
|
< 0.001
|
|
1–4 drugs, n (%)
|
68 (39.5)
|
25 (52)
|
35 (43)
|
8 (19)
| |
|
5–9 drugs, n (%)
|
43 (25.0)
|
3 (6)
|
20 (24)
|
20 (48)
| |
|
≥ 10 drugs, n (%)
|
28 (16.3)
|
1 (2)
|
13 (16)
|
14 (33)
| |
|
Antithrombotic/anticoagulant treat
|
|
Antithrombotic drug, n (%)
|
14 (8.1)
|
1 (2)
|
7 (9)
|
6 (14)
|
0.019
|
|
Anticoagulant drug, n (%)
|
8 (4.7)
|
1 (2)
|
2 (2)
|
5 (12)
| |
|
Non consumption, n (%)
|
150 (87.2)
|
46 (96)
|
73 (89)
|
31 (74)
| |
|
Symptoms
|
|
Fever, n (%)
|
144 (83.7)
|
41 (85)
|
74 (90)
|
29 (69)
|
0.003
|
|
Cough, n (%)
|
140 (81.4)
|
43 (90)
|
68 (83)
|
29 (69)
|
0.039
|
|
Dyspnea, n (%)
|
103 (59.9)
|
29 (60)
|
50 (61)
|
24 (57)
|
0.91
|
|
Gastrointestinal disturbances, n(%)
|
72 (41.9)
|
23 (48)
|
32 (39)
|
17 (40)
|
0.60
|
|
Myalgias, n (%)
|
51 (29.7)
|
15 (31)
|
30 (37)
|
6 (14)
|
0.035
|
|
Thoracic Pain, n (%)
|
27 (15.7)
|
17 (35)
|
9 (11)
|
1 (2)
|
< 0.001
|
|
Pleural chest Pain, n (%)
|
10 (5.8)
|
4 (8)
|
6 (7)
|
0 (0)
|
0.17
|
|
Rhinitis, n (%)
|
8 (4.7)
|
4 (8)
|
4 (5)
|
0 (0)
|
0.17
|
|
Odynophagia, n (%)
|
20 (11.6)
|
8 (17)
|
8 (10)
|
4 (10)
|
0.44
|
|
Asthenia, n (%)
|
47 (27.3)
|
13 (27)
|
20 (24)
|
14 (33)
|
0.57
|
|
Headache, n (%)
|
47 (27.3)
|
13 (27)
|
20 (24)
|
14 (33)
|
0.57
|
|
Dysgeusia, n (%)
|
9 (5.2)
|
6 (12)
|
3 (4)
|
0 (0)
|
0.020
|
|
Anosmia, n (%)
|
2 (1.2)
|
1 (2)
|
1 (1)
|
0 (0)
|
0.65
|
|
Symptoms categorized
|
|
1–3 total symptoms, n (%)
|
97 (56.7)
|
20 (42)
|
41 (51)
|
36 (86)
|
< 0.001
|
|
≥ 4 total symptoms, n (%)
|
74 (43.3)
|
28 (58)
|
40 (49)
|
6 (14)
| |
|
Physical examination
|
|
Temperature, median (IQR), ºC
|
37.2 (36.7, 37.8)
|
37.3 (0.8)
|
37.4 (0.8)
|
37.0 (0.8)
|
0.060
|
|
Heart rate, mean (SD), bpm
|
93.2 (16.1)
|
99.6 (13.8)
|
93.3 (16.5)
|
85.9 (15.1)
|
< 0.001
|
|
Respiratory rate, (median (IQR), rpm
|
16.0 (15.0, 21.0)
|
16.0 (15.0, 16.0)
|
18.0 (15.5, 21.0)
|
22.0 (15.0, 25.0)
|
0.028
|
|
Pulse oximetry, median (IQR), %
|
94.0 (92.0, 96.5)
|
96.0 (94.0, 97.5)
|
94.0 (92.0, 96.0)
|
92.0 (88.5, 94.0)
|
< 0.001
|
|
Normal lung auscultation, n (%)
|
38 (22.1)
|
13 (27)
|
21 (26)
|
4 (10)
|
0.16
|
|
Abnormal lung auscultation, n (%)
|
54 (31.4)
|
12 (25)
|
24 (29)
|
18 (43)
|
0.16
|
|
Blood test
|
|
CRP, median (IQR), mg/L
|
65.3 (29.0, 128.0)
|
57.0 (12.8, 115.0)
|
60.9 (34.0, 135.0)
|
81.5 (45.0, 133.0)
|
0.32
|
|
Lymphocytes, median (IQR), 10e3/ml
|
1100.0 (800.0, 1500.0)
|
1250.0 (1000.0, 1750.0)
|
1000.0 (800.0, 1400.0)
|
900.0 (600.0, 1200.0)
|
0.002
|
|
D-Dimer, median (IQR), μg/L
|
445.0 (288.0, 910.0)
|
410.0 (240.0, 901.5)
|
460.0 (270.0, 880.0)
|
464.0 (320.0, 2160.0)
|
0.39
|
|
Fibrinogen ≥ 500, n (%), mg/dL
|
127 (73.8)
|
31 (65)
|
62 (76)
|
34 (81)
|
0.29
|
|
Ferritin, median (IQR), μg/L
|
443.5 (200.0, 1215.0)
|
474.0 (320.0, 1738.0)
|
494.0 (203.0, 913.0)
|
325.5 (184.5, 1006.5)
|
0.73
|
|
RT-PCR SARS-CoV-2
|
|
Negative, n (%)
|
36 (20.9)
|
17 (35)
|
13 (16)
|
6 (14)
|
0.041
|
|
Positive, n (%)
|
122 (70.9)
|
27 (56)
|
64 (78)
|
31 (74)
|
0.042
|
|
Pneumonia features
|
|
Pneumonia onset, mean (SD), days
|
7.8 (4.1)
|
8.1 (4.7)
|
8.3 (3.8)
|
6.7 (3.7)
|
0.12
|
|
Unilateral, n (%)
|
46 (26.7)
|
21 (44)
|
19 (23)
|
6 (14)
|
0.003
|
|
Bilateral, n (%)
|
126 (73.3)
|
27 (56)
|
63 (77)
|
36 (86)
|
0.004
|
|
Complications
|
|
Hospital admission, n (%)
|
140 (81.4)
|
30 (62)
|
68 (83)
|
42 (100)
|
< 0.001
|
|
Pulmonary thromboembolism, n (%)
|
7 (4.1)
|
2 (4)
|
2 (2)
|
3 (7)
|
0.45
|
|
Death, n (%)
|
11 (6.4)
|
0 (0)
|
2 (2)
|
9 (21)
|
< 0.001
|
