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Domain Study
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A: Substantial variation in selection of patients and GPs1
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A: Risk of bias in selection of patients and GPs1
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B: Risk of bias in data collection and patient flow1
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C: Risk of bias in diagnostic work-up2
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D: Risk of bias in prognostic work-up3
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Ajmi 2011 [16]
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low
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?
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low
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n.r.
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n.r.
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Albert 2011 [17]
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high
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high
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?
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n.r.
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n.r.
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BEACH
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low
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low
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low
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n.r.
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n.r.
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Ben Abdelaziz 2004 [19]
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low
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?
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low
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n.r.
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n.r.
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Coenen 2004 [20]
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?
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low
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?
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n.r.
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?
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CONTENT
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low/?*
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?
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?
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high
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n.r.
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French 2005 [23]
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low
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high
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low
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?
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n.r.
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GRACE
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?/high*
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low
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low/?*
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low/?/high*
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?/high*
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Hamre 2005 [35]
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?
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low
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low
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n.r.
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low
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Harding 1980 [36]
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?
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low
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low
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n.r.
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n.r.
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Hofmans-Okkes 1993 International Study
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?
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low
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low
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n.r.
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n.r.
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Hofmans-Okkes 1993 Dutch Study
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?
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?
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low
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n.r.
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n.r.
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Hull 1969 [38]
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?
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high
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low
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n.r.
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n.r.
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Liu 2017 [39]
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low
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high
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low
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n.r.
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n.r.
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Martin 1984 [40]
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high
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high
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low
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n.r.
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n.r.
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Mash 2012 [41]
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high
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low
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low
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n.r.
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n.r.
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Molony 2016 [42]
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low
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high
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?
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n.r.
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n.r.
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Morrell 1971/1972 [43, 44]
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high
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high
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low
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high
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n.r.
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Munyati 2005 [45]
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high
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high
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low
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low
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n.r.
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NAMCS
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low
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low/?*
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low/?*
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high
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n.r.
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Nantha 2014 [48]
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low
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high
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?
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?
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n.r.
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Njalsson 1992 [49]
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low
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low
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?
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n.r.
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n.r.
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Robertson 1981 [50]
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low
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high
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low
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n.r.
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n.r.
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SESAM 2
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low/high*
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low
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low
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high
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n.r.
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Silva 1998 [53]
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low
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low
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low
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n.r.
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n.r.
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Stefanoff 2014 [54]
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?
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?
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?
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?
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n.r.
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TRANSITION
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low
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low
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low
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high
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n.r.
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Verzantcoort 2018 [56]
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high
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low
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low
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n.r.
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n.r.
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Wong 2016 [57]
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?
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low
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?
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n.r.
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low/?*
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Woolnough 1985 [58]
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?
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high
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?
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low
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n.r.
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Worrall 2008 [59]
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low
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high
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low
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high
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n.r.
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- Legend: ? = unclear, n.r. = not relevant, 1 = refers to all included studies, 2 = refers solely to studies that present data on the underlying aetiologies of cough patients, 3 = refers solely to studies that present prognostic outcomes, * = varying assessments for different publications or different aetiological /prognostic categories
